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Editor,—We read with interest the paper by Mahmudet al (OpenUrlCrossRefPubMedWeb of Science) . The study showed an increased prevalence of methylenetetrahydrofolate reductase (MTHFR) C677T variant in patients with inflammatory bowel disease (IBD). The C677T polymorphism is a known genetic cause of mild hyperhomocysteinaemia (hyper-tHcy)1 and may be associated with a variable degree of risk for thromboembolic disease in patients with IBD.2
To confirm a higher prevalence of the C677T polymorphism, we investigated 99 patients with established IBD for this polymorphism compared with 1084 unselected newborns.3 DNA samples were genotyped for the MTHFR (C677T) mutation. Patients were categorised as homozygous for the thermolabile variant …