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Neurogastroenterology/Motility posters 299–312

https://doi.org/10.1136/gut.50.suppl_2.a82

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    299 CO-EXISTENT FUNCTIONAL DYSPEPSIA (FD) IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS) WORSENS EXTRA-INTESTINAL SYMPTOMATOLOGY AND QUALITY OF LIFE

    E.L. Calvert, L.A. Houghton, P.J. Whorwell.Dept of Medicine, University Hospital of South Manchester, UK

    Extra-intestinal (EI) symptomatology and poor quality of life (QOL) are frequently reported by patients with functional gastrointestinal disorders (FGID), such as IBS and FD1–2. Given that these two conditions often co-exist, it was the aim of this study to assess (i) the frequency of occurrence of FD in patients presenting with IBS and vice versa; (ii) EI symptomatology and QOL in these sub-groups; and (iii) the relationship between FGID symptom severity, EI symptomatology and QOL. A questionnaire addressing FD, IBS (Rome II) and EI symptomatology, and QOL (visual analogue scales) was therefore completed by 80 patients presenting at the out-patients clinic with IBS (20–77 yrs; 64 female) and 77 patients presenting with FD (18–74 yrs; 46 female).

    Results: 52 (65%) of patients with IBS had co-existent FD (IBSFD), whilst 45 (58%) of patients with FD had co-existent IBS (FDIBS). Patients with IBSFD reported a greater number of EI symptoms [20(19,22); mean (95% CI) out of possible total of 31] than patients with FDIBS [17 (15,19); p=0.06], IBS only [13(10,16); p<0.001] or FD only [17(14,19); p=0.08]. In addition, patients with IBSFD had a poorer QOL [28.4(25.5, 31.2)] than those with FD [35.2(31.9,38.4); p=0.02] but not compared with those with FDIBS [32.4(29.3,35.6)] or IBS only [33.4(30.2,36.5)]. Interestingly, poor QOL correlated with the number of EI symptoms reported in all patient sub-groups [IBSFD r=-0.562, FDIBS r=-0.582, IBS r= -0.568, FD r=-0.469; p<0.01]. Furthermore, FGID symptom severity correlated with both the number of EI symptoms and poor QOL in patients with IBSFD [r=0.573, p<0.001; r=-0.333, p=0.017, respectively], FDIBS [r=0.309, p=0.039; r=-0.352, p=0.019] and IBS [r=0.392, p=0.035; r=-0.335, p=0.08] but not those with FD [r=0.095, p=0.6; r=-0.018, p=0.9]. …

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