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Case report
Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction
  1. M G Schäppi1,
  2. V V Smith2,
  3. P J Milla1,
  4. K J Lindley1
  1. 1Department of Gastroenterology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
  2. 2Department of Histopathology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
  1. Correspondence to:
    Dr K J Lindley, Gastroenterology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK;
    K.Lindley{at}ich.ucl.ac.uk

Abstract

The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment.

  • eosinophilic gastroenteropathy
  • interleukin 5
  • myenteric ganglionitis
  • intestinal obstruction
  • EG, eosinophilic gastroenteropathy
  • Th, T helper lymphocyte
  • IL-5, interleukin 5
  • IAS, internal anal sphincter

https://doi.org/10.1136/gut.52.5.752

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