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Letter
Steps forward in understanding gastric cancer risk
  1. Massimo Rugge1,
  2. Robert M Genta2,
  3. Peter Malfertheiner3,
  4. David Y Graham4
  1. 1 Department Medicne - DIMED, University of Padova, Padova, Italy
  2. 2 Pathology, Veterans Affairs North Texas Health Care System, Dallas, USA, Irving, Texas, USA
  3. 3 Radiology, Ludwig Maximilians University Munich, Munchen, Germany
  4. 4 Medicine (111D), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
  1. Correspondence to Professor Massimo Rugge, Department Medicne - DIMED, University of Padova, Padova, Italy; massimo.rugge{at}unipd.it

https://doi.org/10.1136/gutjnl-2022-328514

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    We thank Lenti et al for their interest in our article and their stimulating comments, grounded in their well-recognised experience with gastric autoimmunity.1 2

    The main aim of our study was to assess the neoplastic risk in a cohort of autoimmune gastritis (AIG) patients in whom we excluded previous or current Helicobacter pylori infection.3

    In a recent retrospective clinico-pathological report, Miceli et al studied a cohort of 270 AIG.4 A 19-year follow-up in these patients did not document any incidental gastric cancer (GC). Even after accounting for the different median follow-up times and inclusion criteria, these findings are remarkably similar to those of our long-term follow-up study (median follow-up time: 7 years, equivalent to 10 541 person-years).3 Moreover, Miceli et al document an increased neuroendocrine …

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    Footnotes

    • Contributors All the authors were involved in the conceptualisation and editing of the text.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.