eLetters

299 e-Letters

  • Fetal "Cardiac Mucosa" is not adult cardiac mucosa
    Parakrama T Chandrasoma

    Dear Editor

    I have read with great interest the excellent work by these workers that are published in Gut.[1] Their methods are impeccable and their data are precisely presented and provide valuable insight as to how the esophageal epithelium develops during fetal life. It is a coincidence that the month of April, 2003 also brings two other reports from Korea and Los Angeles on the same subject.[2,3] Two sets of...

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  • Performance of multidetector computed tomography colonography in the detection of colorectal lesions
    Andrea Laghi

    Dear Editor

    We read with interest the recent article by Gluecker et al. (Gut 2002; 51: 207-211) investigating the performance of multidetector computed tomography (MDCT) colonography in the detection of colorectal lesions in comparison with that of conventional colonoscopy. The authors concluded that MDCT colonography provides good sensitivity and specificity for the detection of colonic lesions la...

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  • Author's reply
    Gian Dorta

    Dear Editor

    We read with interest the eLetter of Laghi et al. (14 August 2002).

    We agree with the first comment of Laghi et al. concerning the experience of the investigators. At the beginning of this study, our experience was limited to the cases done for the study published in Gut[1] and to a couple of multidetector computed tomography colonography (MDCT- colonography) in patients with in...

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  • TIPS for gastric varices
    Barbara M Ryan

    Dear Editor

    We recently read with interest the study by Tripathi and colleagues[1] investigating the outcome of TIPS in patients with gastric (GV) compared to oesophageal varices (OV). This study confirmed the previous finding of lower mean portosystemic pressure gradient (PPG) in patients with GV bleeding relative to those with a history of OV bleeding.[2] Indeed in this study 35% (14/40) of GV patients compare...

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  • Obesity as a risk factor for colorectal polyps in Japanese
    Makoto Otsuki

    Dear Editor

    Colorectal cancer (CRC) is one of the most common malignant diseases in the developed countries. Recent epidemiological studies suggest that CRC is associated with obesity.[1,2]

    Although primary prevention of CRC via dietary measures is controversial, secondary prevention by interrupting the adenoma carcinoma sequence is possible. One cross-sectional [3] and a case-control [4] studies have demonstrat...

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  • Pentasa may not be the optimal 5ASA
    John C Mansfield

    Dear Editor

    I read Dr Travis’ Therapy Update [1] with interest, the topic is timely in a market about to be challenged by new generic mesalazine brands. I note the choice of time dependent mesalazine (Pentasa), but, if mesalazine is to be relied upon exclusively, some evidence suggests pentasa may not be the best choice. The recent study by Kruis et al.[2] in the maintenance of remission in ulcerative colitis fo...

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  • Which 5ASA?
    Simon Travis

    Dear Editor

    I am delighted that the Therapy Update on 5-ASA has generated discussion – which is as intended for the series. Articles constrained to 600 words and a dozen references must necessarily be concise, but it would be a colourless author who stayed on the therapeutic fence.

    Pace, Dr Mansfield, the article did not (and I do not) advise exclusive use of Pentasa, nor indeed any mesalazine derivative....

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  • Influence of antisecretory drugs on Helicobacter pylori eradication rates
    Michele Pellegrini

    Dear Editor

    We read with great interest the article by Sherwood et al.[1]

    In their study the authors evaluated the role of acid secretion and gastric luminal pH on the gastric transfer rate of amoxicillin, clarithromycin and metronidazole, showing that metronidazole and clarithromycin but not amoxicillin transfers were increased by acid secretion. The gastric acid suppression, induced by the use...

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  • Diversion colitis with a mucosal tear on endoscopic insufflation
    Yasuhiro Komuro

    Dear Editor

    I read with interest and appreciated the report of Cruz- Correa and colleagues.[1] They show three cases of collageous colitis with mucosal tears on endoscopic insufflation and discussed that there was no report in any other gastrointestinal disease. We would like to present similar mucosal tear on endoscopic insufflation in a patient with diversion colitis.

    A 46-year-old Japanese man presented a...

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  • Authors' reply to Pellegrini et al
    Robin C Spiller

    We thank Dr Pellegrini et al. for their interest [1] in our article.[2]

    As they correctly point out the very effective inhibition of acid secretion may interfere with acid trapping and thus decrease antibiotic transfer into the gastric juice. However, the final antibiotic concentration in gastric juice depends on both the rate of secretion and the rate of degradation. Although metronidazole and amoxycillin ar...

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