eLetters

299 e-Letters

  • Chronic sub-clinical bowel inflammation may explain increased risk of colorectal cancer in the obese
    Biku J John

    Dear Editor,

    We read with interest the recent articles on obesity, inflammation and Colorectal cancer (CRC).1,2,3 Although insulin resistance is the most widely accepted underlying mechanism explaining the association between obesity and CRC, recent evidence suggests that the effects of obesity on the immune system in general and specifically on the gut may play a role. We propose that obesity predisposes to CR...

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  • Prevention of abortion by cyclosporine treatment of fulminant ulcerative colitis during pregnancy
    Sieglinde Angelberger

    Dear Editor,

    Cyclosporine (CsA) is an established treatment in severe, intravenous- corticosteroid-resistant ulcerative colitis (UC). Although one third of UC patients relapse during pregnancy, experience with CsA use during this period is limited to a few case reports.[1][2] Most of the available data on CsA administration and pregnancy outcome have been obtained from the transplantation literature.[3] We read the...

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  • Helicobacter pylori outer membrane proteins and gastric inflammation
    Anar Dossumbekova

    Dear Editor,

    Approximately 4% of the H. pylori genome, significantly more than that of any other known bacterial species is composed of genes encoding outer membrane proteins (OMPs). The best described H. pylori OMP is the adhesin BabA, which is thought to mediate host/bacterial interactions and has been linked to microbial pathogenicity (1-4). The dissection of OMP function helps understanding the complex gastri...

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  • GHRELIN, AUTOIMMUNE GASTRITIS AND ECL HYPERPLASIA
    Fabio Farinati

    Dear Editor,

    We read with interest the well constructed and stimulating review on ghrelin that was recently published in Gut (1). Indeed, the scenario of the hormones and peptides involved in the control of gastrointestinal function, from the point of view of motility or secretion, is getting every year more complicated, with new “players” entering the field (2,3). Ghrelin in particular, making part of the same...

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  • hypoalbuminemia and gastric mass
    JOSEPH BOUJAOUDE

    Dear Doctors,

    Effectively, the biopsies of the gastric mucosa revealed H. Pylori and had been eradicated. But our patient did not improve. It is interresting to look the relation between Menetrier's disease and H Pylori in a multicentric prospective study.

  • Severe recurrent Crohn's disease of ileo-colonic anastomosis and antimicrobial (anti-Mycobacterial)
    Thomas J Borody

    Dear Editor,

    Elliott et al. (Gut 2005; 54: 1818-19) present an interesting and clinically useful finding of successful treatment of a patient with severe Crohn’s disease and circumferential narrowing of the ileo-colonic anastomosis treated with 750 mg ciprofloxacin plus 400mg metronidazole daily for almost three years, resulting in complete healing and opening up of the stenosed anastomosis.

    The author...

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  • Helicobacter pylori and Ménétriers disease
    Guy Sisson

    Dear Editor,

    The Editor’s quiz in Novembers Gut featured a most interesting presentation of Ménétrier’s disease (hypertrophic protein losing gastropathy). There is a recognised association between Ménétriers disease and infection with Helicobacter pylori. In two retrospective studies between 30% and 90% of patients with Ménétriers disease were associated with H pylori1-4. Furthermore, Bayerdörffer et al reported...

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  • Lamivudine in HBV carriers with malignancies
    Ramazan Idilman

    Dear Editor,

    I read with interest the article by Hui et al. reporting hepatitis B reactivation after withdrawal of pre-emptive lamivudine in patients with hematological malignancy on completion of cytotoxic chemotherapy.[1] Reactivation of hepatitis B virus (HBV) infection is a well-recognized complication of chemo/immunosuppressive therapy in HBs-Ag positive inactive carriers.[2][3] It occurs in 14% to 50% of such in...

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  • Complication Rates of Ablation Therapies for HCC: a Difficult Comparison with an Easy Solution
    Vincenzo Arienti

    Dear Editor,

    we read the recent debate from Taipei on which is the best image- guided ablation therapy for Hepatocellular Carcinoma (HCC) by Lin et al (1,2) and Huo et al (3), that represents a interesting topic for hepatologists and gastroenterologists.

    The papers by Lin et al stated that to treat HCC radiofrequency (RFA) was superior to percutaneous ethanol injection (PEI) and percutaneous acetic acid...

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  • Reduced microbial diversity in inflammatory bowel diseases (IBD)
    Stefan Schreiber

    Dear Editor,

    Intestinal microbiota have become subject of intense investigation in inflammatory bowel disease (IBD) during the last years after some groups could demonstrate that significant alterations of the composition of enteric bacteria might be related to the underlying inflammatory process (1-5). However, the complexity of intestinal microbiota and the availability of a variety of different experimental a...

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