299 e-Letters

  • Treatment of ischemia: another promising approach for gastrointestinal complications of radiation
    Tsuyoshi Konishi

    Dear Sir:

    We have read with great interest the review of gastrointestinal (GI) complications after pelvic radiotherapy by Andreyev (1). Andreyev emphasized importance of fibrosis as the underlying cause for most GI symptoms after radiotherapy, and concluded that reversal or prevention of fibrosis could be highly profitable in the treatment of this complication, referring several anti-fibrotic agents such as lipo...

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  • Does Longitudinal Muscle Contraction of Esophagus Hold Important Secrets?
    Neelesh A. Tipnis

    Dear Editor:

    Does Longitudinal Muscle Contraction of Esophagus Hold Important Secrets?

    Tutuian and colleagues [1] performed high resolution esophageal manometry in a patient with achalasia and “chest pressure” following swallowing. They observed a sustained increase in intraesophageal pressure with maximum pressure at the time of maximal esophageal shortening. The esophageal shortening is attributed t...

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  • Re: Is ITPA genotyping predictive for the development of side effects to AZA?
    Jolanda M van Dieren

    Dear Editor,

    In response to the comments of Duley et al. to our letter published in GUT 2005 we would like to make some additional remarks.

    First of all, Duley et al. conclude that our study had a retrospective character, but this is not correct. This is a longitudinal cohort study in which all patients with IBD visiting our out-patient department were included. These patients were followed prospectively fo...

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  • Re: Steatosis in chronic Hepatitis C
    Tarik Asselah

    Dear Editor,

    We appreciate the interest of Guidi et al. according our review about the relevance of steatosis in chronic hepatitis C.[1] We would like to outline three points according to their comments: the prevalence of steatosis in regard to genotype; the role of necroinflammation; the relationship between steatosis and treatment outcome.

    Firstly, several studies have observed a significant association...

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  • Glucocorticoid receptor polymorphisms in inflammatory bowel disease.
    Giuliana Decorti

    Dear Editor.

    We read with interest the article by Mawdsley and Rampton on the relationship between psychological stress, increased disease activity in inflammatory bowel diseases (IBD), and the role of...

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  • 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease
    Dr Prem Chattoo

    Dear Editor,

    We read this article with great interest. Thanks to author for submitting an interesting article. If the patients were on prednisolone or other immunosuppressive drugs then possible effects on CRC risk may be influenced by use of glucocorticoids or immunosuppressant. Question is which drugs really reduce the risk of colorectal cancer risk? As any effect of 5-ASA therapy on the risk of CRC could be me...

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  • Authors' reply to Browning
    Jack Satsangi

    Dear Editor,

    We note Dr Browning's interest in our work. Unfortunately, we find his letter to be factually incorrect, and therefore scientifically misleading.

    In attempting to analyse further our own data, he has made invalid assumptions regarding our data set, which render his calculations inaccurate, and his conclusions inappropriate. Moreover, the selected literature references which he quotes omit c...

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  • Anal fissure treatment with Glyceryl trinitrate vs. Botulinum toxin
    Dr prem chattoo

    Dear Editor,

    We read this article with great interest. Treatment of anal fissure is really troublesome. Here the author puts emphasis on the Neuromyogenic properties of anal sphincter and treatment by topical glyceryl trinitrate, a nitric oxide donor, which decreases anal sphincter tone and improves anal mucosal blood flow and promotes the healing of anal fissures. Because of the easy application process glyceryl tri...

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  • Steatosis in Chronic Hepatitis C
    Marcello Guidi

    Dear Editor,

    we read with great interest the review by Asselah et al. (1), about the relevance of steatosis in chronic hepatitis C. They properly report that steatosis occurs more frequently in patients with chronic hepatitis C (55%) than in the general population (20-30%) of adults in the Western world (2), and that it is associated with various factors, including obesity, high alcohol consumption, diabetes melli...

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  • DLG5 variants and susceptibility to inflammatory bowel disease in the Scottish population
    Brian L Browning

    Dear Editor,

    The recent study by Noble and colleagues[1] did not find an association of the DLG5 G113A polymorphism with either inflammatory bowel disease (IBD) or Crohn’s disease (CD). Previous studies in other European populations had reported an increase in 113A allele frequency in IBD and CD patients [2,3], but, in striking contrast, Noble et al.[1] reported a trend toward decreased carrier frequency for the 1...

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