eLetters

299 e-Letters

  • Sildenafil in gastrointestinal dysmotility disorders
    Atul Scahdev

    Dear Editor

    We read with interest the article by Ehrer A J, et al.[1] the authors have conclusively proven the benefit of sildenafil citrate in reducing the lower oesophageal sphincter pressure and propulsive forces in the body of oesophagus in both healthy subjects and patients with esophageal dysmotility disorders. The beneficial effect was shown to last for upto 8 hours after a single, daily dose of 50...

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  • Repeating the same mistakes as other studies
    Andy R Weale

    Dear Editor

    We read the study by Prantera and colleagues, with great interest. As the authors assert, there have been few good quality and well designed clinical trials, with sufficient power, to examine the effects of probiotics on inflammatory bowel disease.

    This trial unfortunately also has a number of weaknesses both in its reporting and methodology.

    The report does not make clear the exact...

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  • Guidelines for the diagnosis and treatment of cholangiocarcinoma
    Tony CK Tham

    Dear Editor

    We read with interest the British Society of Gastroenterology guidelines for the diagnosis and treatment of cholangiocarcinoma (Gut 2002:51(Suppl VI): 1-9).

    The authors recommend that routine biliary drainage before assessing resectability or preoperatively should be avoided except in the context of acute cholangitis. They do not state the rationale for this approach. Presumably the a...

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  • Antibiotic prophylaxis using cefuroxime in acute pancreatitis
    Thangadorai Amalesh

    Dear Editor

    The UK Guidelines on Acute pancreatitis by the BSG Working party (Gut 1998; 42(suppl 2): S1-13) recommends cefuroxime as the preferred antibiotic in patients with acute severe pancreatitis. This is based on the study by Saino et al.[1] In this randomised, prospective study even though less people in the cefuroxime group died there were 67% of the patients who started treatment with ce...

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  • Pentasa may not be the optimal 5ASA
    John C Mansfield

    Dear Editor

    I read Dr Travis’ Therapy Update [1] with interest, the topic is timely in a market about to be challenged by new generic mesalazine brands. I note the choice of time dependent mesalazine (Pentasa), but, if mesalazine is to be relied upon exclusively, some evidence suggests pentasa may not be the best choice. The recent study by Kruis et al.[2] in the maintenance of remission in ulcerative colitis fo...

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  • Author's reply
    Gian Dorta

    Dear Editor

    We read with interest the eLetter of Laghi et al. (14 August 2002).

    We agree with the first comment of Laghi et al. concerning the experience of the investigators. At the beginning of this study, our experience was limited to the cases done for the study published in Gut[1] and to a couple of multidetector computed tomography colonography (MDCT- colonography) in patients with in...

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  • Performance of multidetector computed tomography colonography in the detection of colorectal lesions
    Andrea Laghi

    Dear Editor

    We read with interest the recent article by Gluecker et al. (Gut 2002; 51: 207-211) investigating the performance of multidetector computed tomography (MDCT) colonography in the detection of colorectal lesions in comparison with that of conventional colonoscopy. The authors concluded that MDCT colonography provides good sensitivity and specificity for the detection of colonic lesions la...

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  • PAIR-derived US-guided techniques for the treatment of cystic echinococcosis: a Chinese experience
    Dominique A. Vuitton

    Dear Editor

    For decades, surgical operation has been considered as the only ideal therapeutic method in the treatment of hydatid cyst/cystic echinococcosis, a parasitic zoonosis that still remains prevalent in a number of countries, and especially PR China where the estimated number of cases is over 500,000.[1] The ultrasound (US)-guided Puncture-Aspiration-Injection -Reaspiration (PAIR) technique [2,3] has now ga...

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  • Postgastrectomy chemoradiotherapy in gastric cancer: More questions than answers?
    Dimitrios H Roukos

    Dear Editor

    The recent report by MacDonald et al., despite provides promising findings for an effective adjuvant chemoradiotherapy of gastric cancer patients after gastrectomy has raised a numerous of questions and criticisms.[1,2] The weakness of this randomized trial and the lack of a surgical quality control have currently been extensively described [1,2,...

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  • Re: Mechanism of stimulation of pepsinogen release by H. pylori
    Sara Lorente

    Dear Editor

    We are very grateful for the interest shown and comments made by Dr Beales regarding our study [1]. We agree with him that it would have been interesting to study the effects of H. pylori infection on the responses to other physiological agonists. Unfortunately, the number of cells obtained from the human stomach with endoscopic biopsies is much lower than that obtained from the entire stomach in expe...

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