eLetters

299 e-Letters

  • The weakest link
    Steven R. DeMeester

    Dear Editor

    Just as the weakest link in a chain determines how much weight the chain will hold, the weakest link in the data used by Fiorica and colleagues will determine how much weight we as readers should give to their findings and conclusions regarding neoadjuvant chemoradiotherapy for esophageal adenocarcinoma.[1]

    Clearly the weakest link in their data is the material by Walsh and colleagues, and prior...

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  • Is this really the current status of small bowel transplantation in the UK?
    Girish L Gupte

    Dear Editor,

    We read with interest the article on ‘The current status of small bowel transplantation in the UK and internationally’ by Middleton et al.[1] This is a timely article about the improving worldwide outcome following small bowel transplantation, but does not fully reflect the status of small bowel transplantation in the UK. In the UK, the Department of Health through NSCAG (National Specialist Commissio...

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  • The toll like receptor-4 gene in IBD: further evidence for genetic heterogeneity in Europe
    Ian DR Arnott

    Dear Editor

    There is now strong evidence implicating the enteric flora in aeitiopathogenesis of IBD and the identification of CARD15 (NOD2) as a pattern recognition receptor (PRR) has given novel insights in to host bacteria interactions. CARD15 is implicated as the intracellular sensor of muramyl dipeptide, a highly conserved bacterial peptidoglycan motif, and raises the question whether other PRRs are involved...

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  • The site distribution of gastrointestinal carcinoids differs between races
    Tsuyoshi Konishi

    Dear Editor,

    We read with great interest the guideline for gastroenteropancreatic neuroendocrine (including carcinoid) tumors by Ramage et al.[1] In this excellent guideline, they reported that appendix is the most frequent site of gastrointestinal primary endocrine tumors, consisting 35% of the total tumors, while colon and rectal carcinoids consisted only 7% and 10%, respectively. One important aspect not ment...

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  • Reply:
    Denis Franchimont

    Dear Editor

    We would like to thank Doctor Ian Arnott for this very interesting comment.[1] Needless to say that we all agree that great caution should apply when reporting positive or negative association studies because of issues such as sample size, cryptic population substructure or phenotype misclassification. To this end, a TDT should always be performed to alleviate skepticism and doubts. It is true that a...

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  • Dental erosion as extraoesophageal manifestation of gastro-oesophageal reflux
    Adolfo Benages

    Dear Editor,

    Dental erosion can be considered as an extraoesophageal manifestation of gastro-oesophageal reflux disease (GORD). Many reports have implicated refluxed gastric acid as a cause or contributory factor in the development of extraoesophageal disorders (“atypical” symptoms related to GORD), but the presence of lesions in oral cavity in patients with acid reflux has been less studied. The association between...

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  • Reply to Franchimont et al
    Servaas A Morré
    Dear Editor

    It is with great interest that we read the paper by Franchimont et al[1] in which they describe a novel association of the Toll-like receptor 4 (TLR4) +896 A>G polymorphism with both Crohn’s disease (CD) and ulcerative colitis (UC), supporting the genetic influence of pattern recognition receptors (PRRs) in triggering inflammatory bowel disease (IBD). PRRs are sensors of pattern associated molecu...

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  • Liver fibrosis assessment by transient elastography in hepatitis C patients with normal ALT
    Ricardo Moreno-Otero

    Dear Editor,

    We read with interest the paper by Foucher et al.[1] where the authors assess the accuracy of transient elastography for the detection of cirrhosis. Its use to assessing the severity of chronic liver disease in other clinical scenarios warrant further evaluations. According to large population studies, the prevalence of chronically hepatitis C virus (HCV) infected patients who have persistently normal...

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  • Authors' reply: Small intestinal transplantation
    Stephen J Middleton

    Dear Editor,

    Dr Gupte and colleagues conclude that our article "does not acknowledge the contribution of the paediatric experience in this developing field" Nonetheless, the article does outline the development of small intestinal transplantation internationally for both adults and paediatrics and includes all of the paediatric outcome data submitted to the international registry, which we believe does include t...

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