eLetters

299 e-Letters

  • Mechanism of stimulation of pepsinogen release by H. pylori
    Ian L. P. Beales

    Dear Editor

    The paper by Lorente et al (Gut 2000; 50: 13-18) demonstrates that H. pylori stimulates pepsinogen release from human chief cells in vitro. The precision of the results obtained from cells from 70 different subjects is to be complimented but several aspects of presentation and interpretation require further discussion.

    The authors report no differences in basal or H. pylori-stimulated pepsinogen...

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  • Further research is needed on the role of TPMT activity in 6 thioguanine prescribing
    Dermot P.B. McGovern

    Dear Editor

    In their letter de Jong et al (Gut 2001;49:874-875) state that in IBD the efficacy and myelotoxicity of 6-mercaptopurine (6-MP) and azathioprine (AZA) are related to the 6-thioguanine (6-TG) levels achieved. It is thought that the 6-thioguanine nucleotides (6-TGN) are the predominantly active metabolite of AZA/6-MP and that efficacy and myelotoxicity seem to be related to 6-thioguanine metabolite level...

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  • Two questions about DA-9601
    David L Elliott
    Dear Editor,

    1) In the authors' studies, or replications by others, were anti-oxidants other than DA-9601 used (e.g. ascorbic acid)?

    2) Have the authors a financial interest in DA-9601?

  • Re: Problems with the diagnosis and treatment of gastric lymphomas
    Shotaro Nakamura

    Dear Editor,

    Dr. Ely seems to have confounded the definition of "high grade component" with that of "high grade MALT lymphoma" in our paper. Based on the previous study by de Jong and colleagues,[1] we used 1% cut off value for the presence or absence of high grade component. When the high grade component cells were less than 10% among the neoplastic lymphoid population, such cases were categorized as low grad...

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  • Problems with the diagnosis and treatment of gastric lymphomas
    S A Ely

    Editor,

    Although it is valuable in some respects, the study from Nakamura et al (Gut 2001;48:454-460) highlights and potentially exacerbates a critical stumbling block in the diagnosis and treatment of gastric lymphomas.

    The authors divide gastric "MALT" lymphomas into low grade and high grade, based on the absence or presence of, "... clusters or sheets of large cells [comprising] at least 1% of the neopla...

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  • Antibiotics for Crohn's disease
    Warwick Selby
    Dear Editor,

    The Therapy Update in the May issue highlighted the potential role for antibiotic therapy in Crohn's disease [1]. Dr Colombel indicated the need for appropriate antibiotics that are based on current theories of pathogenesis, namely that they be effective against both extracellular and intracellular bacteria. The possible role of Mycobacterium paratuberculosis, although controversial, also should not be overl...

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  • HCV and HIV co-infection: who to treat?
    Frank Weilert

    Dear Editor,

    As therapy of HIV patients with HAART has resulted in long-term survival, the major burden of "disease" is becoming end-stage liver disease secondary to HCV infection with rapidly progressive fibrosis and cirrhosis. We are increasingly being asked to advise on this group of patients, however, the literature is cautious about treatment and response rates. Who do we treat? What is the response rate to ac...

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  • Another cause of chest pains
    Carlos A Selmonosky

    Editor,
    Thoracic outlet syndrome is frequently undiagnosed in patients with non-cardiac ,non-coronary chest pains. See www.tos-syndrome.com. Patients with depression or panic attacks can have associated Thoracic Outlet Syndrome. The diagnosis will remain ignored unless the symptoms and physical findings are elicited in these patients.

  • Aerophagia and abdominal migraine as childhood functional gastrointestinal disorders
    Kleomenis Spiroglou

    Editor,

    We read with great interest the article of Rasquin-Weber et al (1), by the title “childhood functional gastrointestinal disorders” in which the authors try to define criteria for functional gastrointestinal disorders in infancy, childhood and adolescence. In this paper the authors consider abdominal migraine as a distinct subgroup of recurrent abdominal pain. Even though it is known for a l...

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