eLetters

299 e-Letters

  • Effect of H. pylori eradication on precancerous lesions
    Derek Gillen

    Dear Editor

    We read with interest the paper by Mera et al1 on the effect of eradicating H. pylori infection on precancerous gastric lesions. However, we have concern regarding the extent to which the limited data provided in the paper support the authors’ conclusions of regression of atrophy and intestinal metaplasia following H. pylori eradication.

    The main outcome reported was the average histological...

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  • Is ITPA genotyping predictive for the development of side effects to AZA?
    John A Duley

    Dear Editor

    In a retrospective study of patients with inflammatory bowel disease, van Dieren et al recently reported the absence of correlation between genotypes for both inosine triphosphate pyrophosphatase (ITPA) thiopurine methyltransferase (TPMT) with any side effects to azathioprine (AZA) (Gut 2005;54:1664). This contrasts with two other studies. A rigorous prospective study recently published has demonstrat...

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  • Tuberculosis & Infliximab
    Christian P Selinger

    Dear Editor

    The introduction of newer TNF blockers (etanercept, infliximab, adalimumab) has greatly improved the treatment of chronic inflammatory disorders such as Crohn’s disease, rheumatoid arthritis and ankylosing spondylitis. As the main side effect however many patients are rendered susceptible to infections.(1) Especially the activation of latent tuberculosis infection (LTBI) is a common and dangerous problem....

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  • Re: Do baseline ALT levels predict complications of chronic hepatitis B?
    Ching-Lung Lai

    Dear Editor We would like to thank Dr Huo and his colleagues for their comments. The followings are point-by-point responses to their comments.

    1) The serum ALT levels were not considered in our analysis of prognostic factors because the stratification into 5 groups rendered it too complicated for statistical calculation of multivariate analysis. In addition, we aimed to examine independently the differences...

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  • Ghrelin: a new player in the control of gastrointestinal function
    Oscar, M Jolobe

    Dear Editor,

    Arguably, the two most powerful endogenous appetite stimulants are ghrelin[1] and the cannabinoids.[2] What is not known is whether or not they interact, and whether there is mutual reinforcement of their individual actions. If it were the case that cannabinoids and ghrelin are synergistic, coprescription of the two agents (delta 9-tetrahydrocannabinol being the approved appetite enhancing pharmacologic...

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  • Do baseline ALT levels predict complications of chronic hepatitis B?
    Teh-Ia Huo

    Dear Editor,

    We read with interest the paper by Yuen et al. published in a recent issue of Gut.[1] This study included a large patient cohort with chronic hepatitis B and analyzed the determinants predicting the outcome. Authors concluded that low level viremia and mildly elevated serum ALT levels more commonly lead to the development of complications. This conclusion, however, is not supported by their findings...

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  • Stratification by gender and subgroup is necessary for RCT on IBS
    Zhaoxiang BIAN

    Dear Editor,

    We read with great interest the paper by Antonius Schneider et al. assessing acupuncture treatment in irritable bowel syndrome (IBS).[1] They successfully recruited 43 patients with IBS according to Rome II criteria, and randomly assigned them to receive either acupuncture (n=22) (AC) or sham acupuncture (n=21) (SAC) using the so-called "Streitberger needle". Treatment duration was 10 sessions with an...

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  • Dyspepsia is distinguishable from heartburn
    Michael Camilleri

    Dear Editor,

    This systematic, original large study from the Leuven group proves what experienced physicians have appreciated for many years: that heartburn is a specific symptom that is easily identifiable by careful history or validated questionnaire, that heartburn is predictive of abnormal esophageal acid exposure in about 75% of people with the symptom, and that it occurs in a minority of patients with typical...

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  • Lower insulin resistance and antiviral therapy response in HCV-related chronic hepatitis
    Giovanni Tarantino

    Dear Editor,

    According to a recently published study[1], insulin resistance is a worsening factor in HCV-related chronic hepatitis. There is much debating as to whether insulin resistance depends on hepatitis C virus or, vice versa, it is an independent syndrome.

    Likely, being insulin resistance the link between obesity, metabolic alterations and endothelial damage, it is a characteristic feature of the met...

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  • Bravo vs. catheter pH monitoring
    Mark R Fox

    Dear Editor,

    Pandolfino et al. and Bruley des Varannes et al. present data from simultaneous pH monitoring by wireless Bravo™ and catheter mounted antimony electrode systems.[1,2] Both studies demonstrate that the wireless system records significantly fewer reflux events; the effect on overall acid exposure was more limited. Further analysis revealed that events ‘missed’ by the Bravo™ system were shorter and less...

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