eLetters

299 e-Letters

  • The stomach peri-glandular fibroblast sheath: All present and correct
    Simon J Leedham

    Dear Editor,

    We were interested in the paper by Mutoh et al.[1], showing the development of epithelial intestinal metaplasia and mesenchymal proliferation in human stomach resections and Cdx2 transgenic mice. The authors used alpha-smooth muscle actin (alpha-SMA) staining to mark peri-glandular fibroblasts and failed to show any alpha-SMA positive cells surrounding the en-face glands of normal mouse and human stomach m...

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  • Complications of radiofrequency ablation in hepatocellular cancer: what about "exoplosive spread"?
    Fabio Farinati

    Dear Sir,

    Surgery (resection or transplantation) is the first treatment choice for early HCC, but unfortunately it is feasible only in a minority of patients.[1] Local percutaneous ablation has therefore dramatically increase in importance and radio-frequency thermal ablation (RFTA) has showed in recent reports global or disease-free survivals better than those reported for percutaneous ethanol injection (PEI).[2] The...

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  • Mycobacteria avium paratuberculosis: a major cause of Crohn's disease
    J. Todd Kuenstner

    Dear Editor,

    I would like to respond to the commentary written by Dr. R. Balfour Sartor entitled, "Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease?” The answer to this rhetorical question is yes, and I would like to explain why we now have sufficient information to conclude that Mycobacterium avium paratuberculosis (Map) is a major cause of Crohn's disease.

    First, I will address...

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  • Anti-saccharomyces cerevisiae antibodies (ASCA) in coeliac disease
    Alessandro Granito

    Dear Editor,

    We read with great interest the paper by Israeli et al. assessing the presence of anti-Saccharomyces cerevisiae antibodies (ASCA) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) before the occurrence of overt clinical manifestations in patients with Crohn’s disease (CD) and ulcerative colitis (UC).[1] They found that ASCA were present in 31% CD patients before clinical diagnosis (but no...

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  • Slow transit through the large intestine, deoxycholic acid and cholesterol gallstones
    Martin C Carey

    Dear Editor,

    The recent paper by Thomas and colleagues[1] in the May 2005 issue of Gut provides further support for an involvement of increased colonic deoxycholic acid formation and absorption in cholesterol gallstone pathogenesis. This paper and others in the series[2-4] from Professor R. Hermon Dowling’s laboratory at Guy’s Hospital, London, was ably placed in perspective with the accompanying comprehensive co...

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  • Risk of lymphoma: inflammatory bowel disease and immunomodulators
    Yeng S Ang

    Dear Editor,

    We read with great interest the meta-analysis by Kandiel et al., (Gut 2005; 54: 1121-1125) the purpose of which was to provide a more precise estimate of the relative risk of lymphoma among inflammatory bowel disease (IBD) patients treated with azathioprine or 6-mercaptopurine (6-MP). Based on the six studies included in their meta-analysis, Kandiel et al., determined that the risk of lymphoma among...

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  • Hepatitis C Virus Infection in Italy: A Dynamic Event
    Silvia Sereno

    Dear Editor,

    We read with great interest the article by Bartolotti et al. (Gut2005;54:852-857) regarding the shift in the predominance of hepatitis C genotype in 373 paediatric patients investigated between 1990 and 2002. The distribution of genotypes showed a major prevalence of HCV genotype 1, recorded in about 60% of children. The genotype 2, 3 and 4 were observed in 17, 15 and 5% of patients respectively. However...

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  • Lactose malabsorption and colorectal cancer: what is the role in asymptomatic patients?
    Massimo Montalto

    Dear Editor,

    We read with considerable interest the article by Jarvela et al. (Gut 2005;54:643-647), who investigate the relationship between the genotype of adult-type hypolactasia and the risk of colorectal cancer in the Finnish, British, and Spanish populations. In this study, the C/C–13910 genotype, a robust molecular marker of lactase non-persistence[1], was found to significantly associate with the risk of c...

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  • Hyperhomocysteinaemia and vascular disease in liver patients
    Giampaolo Bianchi

    Dear Editor,

    We read with interest the case report by Buchel et al., published on the July issue.[1] The authors report a patient with portal hypertension, nodular regenerative hyperplasia and portal thrombosis that presented an avascular hip necrosis after a liver transplantation (OLT). The authors suggest that the whole clinical picture might stem from hyperhomocysteinaemia (high Hcy) and 677C->T heterozigosi...

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  • Concerns regarding evidence for the recommendation of naso-gastric feeding in acute pancreatitis
    Liesl Wandrag

    Dear Editor,

    We have concerns about the recommendation of naso-gastric feeding in severe acute pancreatitis. Firstly, the recommendation is based on a feasibility study of 26 patients published in August 2000 in the International Journal of Pancreatology.

    Secondly, it has been graded as grade B evidence. We therefore feel that this recommendation is misleading and inappropriate. We feel further evidence...

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