eLetters

299 e-Letters

  • Adoptive transfer of genetic susceptibility to Crohn's disease?
    Christian Folwaczny

    Dear Editor

    We read with great interest the stimulating case report about fulminant Crohn’s colitis following allogenic stem cell transplantation by Sonwalkar and colleagues [1] and the respective editorial.[2] The authors and the editorialists hypothesize whether the colitis might be ascribed to the adoptive transfer of stem cells displaying genetic alterations which are associated with Crohn’s disease. However, the i...

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  • Author's reply
    Peter J. Whorwell

    Dear Editor

    John Hunter states that the generally held view is that IgG testing for food intolerance is not of value and gives references in support of this contention.[1] However, the consensus of these papers and others is that the research is of poor quality and better designed studies are needed to resolve this question. Designing trials in this field, which meet all the criticisms that can be levelled at t...

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  • Author's reply
    Peter H. R. Green

    Dear Editor

    In their BSG National Survey [1] the authors relied mainly on gastroenterologists and surgeons to report cases of small bowel carcinoma and whether they were associated with either coeliac or Crohn’s disease. This may have resulted in underestimation of associated coeliac disease. In our series we had two cases in which the original pathologist had failed to recognize the histologic features of coel...

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  • Mechanism of stimulation of pepsinogen release by H. pylori
    Ian L. P. Beales

    Dear Editor

    The paper by Lorente et al (Gut 2000; 50: 13-18) demonstrates that H. pylori stimulates pepsinogen release from human chief cells in vitro. The precision of the results obtained from cells from 70 different subjects is to be complimented but several aspects of presentation and interpretation require further discussion.

    The authors report no differences in basal or H. pylori-stimulated pepsinogen...

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  • IgG anti-betalactoglobulin in children with IBS symptoms: a valid aid to decide for the elimination
    Antonio Carroccio

    Dear Editor

    We applaud the very elegant study by Atkinson and colleagues, who demonstrated that the assay of IgG antibodies to food may have an important role in helping patients and clinicians identify candidate foods for elimination, with consequent significant improvement of irritable bowel syndrome (IBS) symptoms.[1] For more than 10 years we have assayed IgG anti- betalactoglobulin in children to help us in the...

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  • In search of the correct strategy for preventing the spread of HCV infection...
    Maurizio Montella

    Dear Editor

    Hepatitis C virus (HCV) infection is definitely an emerging, global healthcare issue. Besides affecting approximately 3% of the world population, HCV is also a silent disease - the majority of incidences go unrecognized and serve unknowingly as sources of infection to others.[1,2] Add to that the scant information in existence defining HCV’s transmission routes and rates, the program presented by Skipper...

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  • Re: Mechanism of stimulation of pepsinogen release by H. pylori
    Sara Lorente

    Dear Editor

    We are very grateful for the interest shown and comments made by Dr Beales regarding our study [1]. We agree with him that it would have been interesting to study the effects of H. pylori infection on the responses to other physiological agonists. Unfortunately, the number of cells obtained from the human stomach with endoscopic biopsies is much lower than that obtained from the entire stomach in expe...

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  • A letter in response to “What is the best management strategy for high grade dysplasia in Barrett’s
    Chin Hur

    Dear Editor

    The study by Shaheen and colleagues[1] is the results of a decision analysis model which determined the cost effectiveness of various management strategies for high grade dysplasia in Barrett’s oesophagus. We were surprised to note that the authors of this article did not reference our analysis which was published over a year ago in July 2003.[2] Our model and analysis had conclusions that were identica...

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  • Author's response
    Peter W. Angus

    Dear Editor

    In response to Helmy's comments we wish to emphasise the following points, many of which were clearly stated in our original manuscript.[1]

    In agreement with the comments on "generalised vasodilatation" in cirrhosis, we made it clear that basal forearm blood flow was normal in our patient cohort despite the presence of a vasodilated circulation, as evidenced by a reduced SVRI. As pointed...

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  • Postgastrectomy chemoradiotherapy in gastric cancer: More questions than answers?
    Dimitrios H Roukos

    Dear Editor

    The recent report by MacDonald et al., despite provides promising findings for an effective adjuvant chemoradiotherapy of gastric cancer patients after gastrectomy has raised a numerous of questions and criticisms.[1,2] The weakness of this randomized trial and the lack of a surgical quality control have currently been extensively described [1,2,...

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