eLetters

299 e-Letters

  • Mycobacterium avium paratuberculosis (MAP): cause of Crohn's Disease (CD) vs. contribution to pathog
    Robert L Clancy

    Dear Editor,

    The preoccupation with the question of whether or not MAP is the cause of CD has split the gastroenterological world into ‘believers’ and ‘non believers’ with much fervour and polarity such that a likely middle- ground could be neglected. The current argument is simplistic and fails to consider the complexity of the many environmental and genetically determined defects of immune regulation and barrier...

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  • Future use of the Glasgow alcoholic hepatitis score
    I N Guha

    Dear Editor,

    We read with interest the findings of Forrest et al ; Gut 2005; 54: 1174-1179, regarding their prognostic algorithm for alcoholic hepatitis; Glasgow alcoholic hepatitis score (GAHS). The study uses robust clinical end-points to develop an algorithm that has diagnostic advantages over the modified discriminant function score (DFS). We would like to discuss some of the future implications of this importa...

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  • A new entity of hereditary colorectal cancer
    Jeremy R Jass

    Dear Editor,

    Mueller-Koch et al. in Gut 2005 June 14th (Epub) describe clinical and molecular evidence for a 'new entity' of hereditary colorectal cancer. Clustering of colorectal cancer (CRC) within families has been known for some time [1] and it is not surprising that some such families will meet the Amsterdam Criteria (AC) even though they do not carry a germline mutation in a DNA mismatch repair gene. It has bee...

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  • Cannabinoid hyperemesis: normalization of gastric motility after cessation of use
    NOEL R FAJARDO

    Dear Editor,

    We have been following the case of a 41 year old male with spontaneous and recurrent episodes of vomiting occurring regularly in a cycle every 4-6 months, separated by symptom-free intervals, which started 5 years ago. Endoscopy and imaging studies were negative for disease. He is healthy and does not have any other active medical problems. He admitted to be a daily marijuana user for the past 20 years....

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  • Tuberculous colitis
    Hans Scherubl

    Dear Editor,

    With great interest we read the tutorial by Forbes. We would like to stress that the count of CD4 lymphocytes (and possibly immunoglobulines) might be quite helpful in the differential diagnosis of chronic inflammatory bowel disease and tuberculosis as evidenced by the following case report:

    A 35-year-old Iranian patient presented to our clinic with chronic diarrhea, intermittent abdominal pa...

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  • Is emergency medicine underepresented in the UK guidelines for the management of acute pancreatitis?
    John M Ryan, Alistair Murray, Sarah O Connell, Tulo Alugo

    Dear Editor,

    We read with interest the latest guidelines for the management of acute pancreatitis. We noted no mention of emergency medicine in the guidelines and in particular we did not identify any emergency physician in the working party. Was the British Association for Emergency Medicine consulted during the production of the guidelines?

    Patients with acute pancreatitis most frequently present to emer...

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  • Authors' reply
    Jens Werner

    Dear Editor,

    We thank Dr. Jolobe very much for his letter which mentions the difficulty of establishing the diagnosis of acute pancreatitis in patients with diabetic ketoacidosis.

    We did not address diagnostic tests and medical intensive care treatment of acute pancreatitis in the present article, but reviewed the interventional and surgical treatment strategies in acute pancreatitis. There is no doubt...

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  • Proposal of new prognostic models for HCC: a scientific innovation or a modern "Tower of Babel"?
    Georgios C. Sotiropoulos

    Dear Editor,

    Tateishi et al. in a recently publication in Gut (2005;54:419-425) proposed the “Tokyo score”, a new prognostic model for hepatocellular carcinoma (HCC). This score consists of four factors: serum albumin, bilirubin, size and number of tumours. This model was established by analysing survival time among HCC patients treated with medical ablation. HCC was detected with ultrasound and/or computed tomo...

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  • Statistical points arising from Author’s Reply
    Michael E Weale

    Dear Editor,

    I write as the statistician on the paper by Mulcare and collaborators [1] which was criticised by Drs Kolho and Järvelä in their "Author's Reply" eLetter to Gut Online. I wish to correct two assertions made by Drs Kolho and Järvelä. The first is their claim that our statistical procedure “contains a risk for wrong conclusions” because “adult-type hypolactasia is difficult to assess due to inaccurate d...

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  • Acylated ghrelin stimulates food intake, but des-acylated ghrelin has no effect
    Stephen R Bloom

    Dear Editor,

    We were interested to read the article of Asakawa et al. Gut 2005;54:18-24 which reported that ICV and peripheral administration of des -acylated ghrelin inhibited food intake in mice in the fasted state. Acylated ghrelin (AG) has a unique biological structure with an acyl side chain on the 3rd amino acid residue. AG is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a) [1] and...

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