eLetters

299 e-Letters

  • Endocinch® treatment for GORD: where it stands
    Zahid Mahmood

    Dear Editor,

    We read with great interest the article by Schiefke et al. (Gut 2005; 54: 752-758) on the long term failure of endoscopic gastroplication (Endocinch). The authors reported more than 80% of patients had lost at least one suture and only 17% had all sutures in situ after 18 months (clip device). The loss of plications has been reported both with knot [1] as well as clip device [2] used for anchoring sut...

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  • PMS2 mutations in childhood cancer
    David T Bonthron

    Dear Editor,

    We refer to the recent paper by Durno et al. "Family history and molecular features of children, adolescents and young adults with colorectal carcinoma" (doi:10.1136/gut.2005.066092).

    Among other patients with early-onset colorectal cancer (CRC), the authors discuss a girl with CRC onset at age 12, and a subsequent second primary tumour (glioblastoma). This patient appears t...

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  • Epithelial cells in bone marrow: do they matter?
    Willam A Marsman

    Dear Editor,

    With great interest we have read the letter of Steinert et al. in a recent issue of Gut.[1] They describe disseminated epithelial cells in the bone marrow of patients with colorectal adenomas. As adenomas are non -cancerous, it is questionable whether these epithelial like cells really represent disseminated cancer cells. If so, the benign nature of intraepithelial neoplasia is basically challenged....

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  • An Unusual Case of Soft Tissue Infection
    Jeffrey P Garner

    Dear Editor,

    The case presented in the Editor's Quiz raises several issues regarding compartment syndromes and the timing of interventions and the nomenclature of necrotising infections and their surgical treatment.

    Gas within the muscle compartments on plain radiography not only suggests a gas forming myonecrotic infection, particularly in a diabetic patient, but also a high probability of a compartment...

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  • Cap polyposis: an inflammatory disorder or a spectrum of mucosal prolapse syndrome?
    Tsuyoshi Konishi

    Dear Editor,

    We have read with great interest the letter by Maunoury et al.[1] They reported on a case of cap polyposis unresponsive to infliximab, in contrast to the successful report by Bookman et al. [2] Maunoury et al. stated that an infliximab success by Bookman et al. might have been due to a spontaneous regression of cap polyposis. Maunoury et al. speculated that a role of TNF-ƒ¿ in the pathogenesis of thi...

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  • Lack of serum antibodies to membrane-bound carbonic anhydrase iv in primary biliary cirrhosis
    Pietro Invernizzi

    Dear Editor,

    Nishimori and colleagues have recently reported the presence of autoantibodies against carbonic anhydrase IV (anti-CA IV) in patients with autoimmune pancreatitis.[1] Further, serum antibodies to CA II (anti-CA II) were observed in several autoimmune conditions. We have now investigated the presence of anti-CA IV and anti-CA II in a large series of sera from patients with primary biliary cirrhosis (P...

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  • Authors' Reply to Byrne et al.
    James H Allen

    Dear Editor,

    We would like to thank Byrne et al. for their interest in our Paper.[1] It should be noted that we undertook an observational study by necessity. Cannabis is an illegal drug and double blind control trials with illicit substances are prohibited and unethical. The assertion that cannabis has been “consumed for many centuries” needs to be tempered with the fact that cannabis has been grossly nder-res...

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  • Author's reply
    Mamadou Baldé

    Dear Editor,

    We took note with interest of the letter of RK Russell et al. of April 19, 2005, concerning the link between passive smoking and the risk of IBD in children.

    We agree with them that it is important to take into account the role of passive smoking not only during childhood and at disease onset but also during the perinatal period. We also looked at this point in our study but came to differe...

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  • ITPA genotyping is not predictive for the development of side effects in AZA treated IBD patients
    Jolanda M van Dieren

    J.M. van Dieren, A.J. van Vuuren, J.G. Kusters, E.E.S. Nieuwenhuis, E.J...

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  • Chronic inflammatory intestinal diseases and bone loss
    Maria Teresa Bardella

    Dear Editor,

    We were very interested in the recent article by Moschen et al. on the activation of RANKL/OPG system in inflammatory bowel disease (IBD). Until recently, osteoporosis secondary to gastrointestinal diseases was mainly considered a direct consequence of malabsorption [2,3]. The article of Moschen et al. [1] and a previous one of our group on bone loss in celiac disease [4], a disorder similarly char...

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