eLetters

299 e-Letters

  • Author's reply
    Lieven Dupont

    Dear Editor,

    We are thankful to Dr Luigi Benini et al. for their comments on our article [1]. We appreciated their reading of our manuscript, which led them to question the relevance of the temporal relationship between reflux and cough. However, we disagree with the authors of the e-letter with regard to their statement that "the temporal association of reflux with cough does not appear a reliable criterion to di...

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  • Authors' reply
    Andrew K Burroughs

    Dear Editor,

    We are grateful to Such and colleagues for their comments about our review [1,2]. As we had outlined, the influence of bacterial infection on the pathophysiology of cirrhosis is indeed an important one and Such and coworkers have contributed significantly to this topic [3-6]. We were aware of their data, but unfortunately some of it could not be retained in the final version of our paper due to edi...

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  • Persistent dyspeptic symptoms in long-standing ulcerative colitis
    Helga P. Török

    Dear Editor,

    We read with great interest the stimulating article by D’Argenio and co-workers about the differential expression of transglutaminses in ulcerative colitis [1]. As discussed by the authors and the accompanying editorialists, [2] this study provides important evidence for a role of transglutaminases in the mucosal healing process in ulcerative colitis.

    Herein, we describe the case of a 71 y...

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  • Soluble interleukin-2 receptors as a predictor of therapeutic response in ulcerative colitis
    Tom J Creed

    Dear Editor,

    We agree with Gustot et al. that soluble cytokine receptors have an important role in the immune regulation of inflammatory bowel disease, and that there is a variable change in soluble cytokine receptors in response to treatment.

    We postulated that a change in soluble cytokine receptor levels following the administration of corticosteroids may be useful in predicting therapeutic response to...

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  • 'Cannabis hyperemesis' causation questioned
    Andrew Byrne

    Dear Editor,

    These authors describe a number of cases of a bizarre syndrome of severe vomiting, abdominal symptoms leading to dehydration in combination with repetitive bathing behaviour. They have concluded that these symptoms are due to cannabis use.

    Cannabis has been consumed for many centuries and is currently used by millions of people in many countries. It is hard to believe that a distinctive s...

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  • Reflux-associated cough usually is not associated with a reflux: the role of reduced cough threshold
    Luigi Benini

    Dear Editor,

    We read with great interest the article by Sifrim and co-workers [1] addressing the issue of the importance of weakly acidic reflux (as measured by 24 hour ambulatory pressure and pH-impedance monitoring) in patients with chronic cough. The presence of asthma, postnasal drip, or the use of ACE inhibitors was ruled out, so that an association with gastro-oesophageal reflux was probable. They found th...

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  • Perinatal passive smoke exposure and risk of developing Childhood IBD
    Richard K Russell

    Dear Editor,

    The large case-control study of patients with inflammatory bowel disease in the French Paediatric population by Baron et al. has clarified the role of well established genetic and environmental risk factors, as well as suggesting novel environmental risk factors [1].

    However, we caution the authors on the dismissal of the role of passive smoking in the risk of IBD development in childhood....

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  • Author's reply
    Francesco Costa

    Dear Editor,

    We are thankful to Marc Lemann and Jean-Yves Mary for their poignant comments on our article [1] that appeared in a recent letter to Editor [2]. We appreciated their careful reading of the text, and their questioning the validity of our study gives us a unique opportunity for further articulating our findings.

    We agree with the authors that other methods could be used instead of the ROC cu...

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  • Author's reply
    Kaija-Leena kolho

    Dear Editor,

    Dr Swallow raises a question about another DNA-variant underlying adult- type hypolactasia in sub-Saharan populations and does not recommend the analysis of the C/T-13910 variant as a genetic test in African and non-Northern European populations. Although the studies performed by us [1-3] and others [4-5] do not support the existence of another variant, we agree with Dr. Swallow that well-conducted s...

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  • Response to steroid therapy of sclerosing cholangitis after duodenopancreatectomy due to autoimmune
    David Padilla

    Dear Editor,

    Autoimmune pancreatitis is a chronic inflammation of the pancreas due to etiopathogenic mechanisms of autoimmunity. There are no established definitive diagnostic criteria, although histological, analytical and radiological characteristics do enable us to identify this entity in the differential diagnosis with chronic alcoholic pancreatitis and cancer of the pancreas [1,2,3]. Nevertheless, this is no...

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