TY - JOUR T1 - Carrageenan-induced ulceration of the large intestine in the guinea pig JF - Gut JO - Gut SP - 164 LP - 171 DO - 10.1136/gut.12.2.164 VL - 12 IS - 2 AU - J. Watt AU - R. Marcus Y1 - 1971/02/01 UR - http://gut.bmj.com/content/12/2/164.abstract N2 - A 5% aqueous solution of degraded carrageenan derived from the red seaweed Eucheuma spinosum was fed to guinea pigs in their drinking water over a period of 20-45 days. Occult blood in the faeces and multiple ulcers in the caecum, colon and rectum occurred in 100% of animals by the 30th day. The clinical and pathological features bear a close resemblance to human ulcerative colitis. The method provides a simple experimental model for the study of various aspects of the pathology of ulcerative lesions in the large intestine as well as the effects of therapeutic agents. ER -