RT Journal Article SR Electronic T1 Lymphocyte transformation in the mesenteric lymph nodes of patients with Crohn's disease JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 20 OP 24 DO 10.1136/gut.14.1.20 VO 14 IS 1 A1 Guillou, P. J. A1 Brennan, T. G. A1 Giles, G. R. YR 1973 UL http://gut.bmj.com/content/14/1/20.abstract AB The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subjects. The impaired responses of circulating lymphocytes from these patients were marked on culture in autologous serum and were not improved by culture in homologous AB serum. Lymphocytes from lymph nodes directly draining diseased bowel exhibited lower responses than those from nodes at the root of the mesentery, which in turn were lower than those of circulating lymphocytes.