RT Journal Article SR Electronic T1 Serum cobalt-activated acylase and gamma-glutamyl transpeptidase activities in toxic hepatitis. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 626 OP 629 DO 10.1136/gut.16.8.626 VO 16 IS 8 A1 A Szczeklik A1 A Wiernikowski A1 J Musial A1 E Woźny YR 1975 UL http://gut.bmj.com/content/16/8/626.abstract AB Marked activity of cobalt-activated acylase was found in the sera of 33 of 37 patients with acute toxic hepatitis due to poisoning with either amanita mushrooms or chemicals. The activity of the enzyme showed a positive correlation with that of serum transaminases, reached the highest levels on the patient's admission to hospital and within a few days fell rapidly to undetectable levels. Slight acylase activity was observed in the majority of patients intoxicated with drugs or carbon monoxide but was not seen in sera of those poisoned with non-amanita mushrooms who showed no signs of liver injury. Unlike acylase, the serum activity of gamma-glutamyl transpeptidase remained unchanged over the first days of acute toxic hepatitis. The determination of serum cobalt-activated acylase might be of value in the diagnosis of acute liver injury.