RT Journal Article
SR Electronic
T1 Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 201
OP 204
DO 10.1136/gut.16.3.201
VO 16
IS 3
A1 R Allan
A1 D M Steinberg
A1 K Dixon
A1 W T Cooke
YR 1975
UL http://gut.bmj.com/content/16/3/201.abstract
AB Bidirectional sodium flux across the intestinal mucosa was measured in a group of 10 patients with Crohn's disease treated in the past by panproctocolectomy with ileostomy and compared with a similarly treated group of 11 patients with ulcerative colitis. All of them were in good health at the time of the study and a recent radiological examination of the small intestine was normal. A significant reduction in bidirectional sodium flux was found in those patients with Crohn's disease and suggests that the intestinal mucosa is involved to a greater extent than can be judged by radiological appearances alone. This adds weight to the concept that Crohn's diseases is a diffuse rather than a focal lesion of the gastrointestinal tract.