RT Journal Article SR Electronic T1 Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 913 OP 918 DO 10.1136/gut.18.11.913 VO 18 IS 11 A1 Korbová, L A1 Kohout, J A1 Malis, F A1 Balas, V A1 Cízková, J A1 Marek, J A1 Cihák, A YR 1977 UL http://gut.bmj.com/content/18/11/913.abstract AB Cycloheximide, 5-azacytidine, and 4-methoxybenzoyl-beta-bromoarylate (Cytembena) block the development of experimental acute pancreatitis in rats when mediated by the administration of 5% bile solution into the pancreas in vivo. Six hours after drug treatment the pathological changes, evaluated macroscopically or using histological sections of the pancreas, were significantly decreased. The drugs affected the amount of abdominal fluid and lowered its lipase and amylase activity. The known inhibitory mechanism of the active drugs and the possible advantage of cycloheximide for clinical use are briefly mentioned.