PT  - JOURNAL ARTICLE
AU  - M G Bryant
AU  - S R Bloom
TI  - Distribution of the gut hormones in the primate intestinal tract.
AID  - 10.1136/gut.20.8.653
DP  - 1979 Aug 01
TA  - Gut
PG  - 653--659
VI  - 20
IP  - 8
4099  - http://gut.bmj.com/content/20/8/653.short
4100  - http://gut.bmj.com/content/20/8/653.full
SO  - Gut1979 Aug 01; 20
AB  - Reliable and specific radioimmunoassays have been developed for the gut hormones secretin, gastrin, cholecystokinin, pancreatic glucagon, VIP, GIP, motilin, and enteroglucagon. Using these assays, the relative pattern of distribution of the gut hormones has been determined using the same bowel extracts for all measurements. VIP occurred in high concentration in all regions of the bowel, whereas secretin, GIP, motilin, and CCK were predominantly localised in the proximal small intestine. Pancreatic glucagon was almost exclusively confined to the pancreas. Like VIP, enteroglucagon also exhibited a wide pattern of distribution but was maximal in the ileum. The acid ethanol extraction method that was used was found to be unsuitable for gastrin. On gel chromatography of the extracts, motilin and VIP eluted as single molecular species in identical position to the pure porcine peptides. CCK, pancreatic glucagon, enteroglucagon and GIP were all multiform.