RT Journal Article
SR Electronic
T1 Reappraisal of the secretory potency and disappearance rate of pure human minigastrin.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 705
OP 708
DO 10.1136/gut.20.8.705
VO 20
IS 8
A1 Carter, D C
A1 Taylor, I L
A1 Elashoff, J
A1 Grossman, M I
YR 1979
UL http://gut.bmj.com/content/20/8/705.abstract
AB The secretory potency and disappearance rates of pure synthetic human non-sulphated minigastrin (HG-14-I) and pure natural human non-sulphated heptadecapeptide (HG-17-I) were compared in five dogs with gastric fistulas and Heidenhain pouches. Intravenous infusion of equimolar doses of the two gastrins produced equimolar increases over basal of serum immunoreactive gastrin and no statistically significant differences in acid output. Also HG-14-I and HG-17-I did not differ significantly in half-times for disappearance, clearance rates, calculated volumes of distribution, or mean plateau serum levels.