TY - JOUR T1 - Virus isolation studies in Crohn's disease: a negative report. JF - Gut JO - Gut SP - 1057 LP - 1062 DO - 10.1136/gut.20.12.1057 VL - 20 IS - 12 AU - R J Phillpotts AU - J Hermon-Taylor AU - B N Brooke Y1 - 1979/12/01 UR - http://gut.bmj.com/content/20/12/1057.abstract N2 - Homogenates of gut and mesenteric lymph node tissue from patients with Crohn's disease, ulcerative colitis, and control patients were tested for cytopathic effect (CPE) production in a series of cell lines including rabbit ileal and W138 cells. A CPE was produced in W138 cells by tissue homogenates from patients with Crohn's disease, ulcerative colitis, and control patients. Evidence was obtained to suggest that this effect, although superficially similar to a viral CPE, was due to toxic protein constituents of inflamed tissue homogenate. ER -