PT  - JOURNAL ARTICLE
AU  - Konturek, S J
AU  - Brzozowski, T
AU  - Piastucki, I
AU  - Radecki, T
TI  - Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
AID  - 10.1136/gut.23.6.536
DP  - 1982 Jun 01
TA  - Gut
PG  - 536--540
VI  - 23
IP  - 6
4099  - http://gut.bmj.com/content/23/6/536.short
4100  - http://gut.bmj.com/content/23/6/536.full
SO  - Gut1982 Jun 01; 23
AB  - Paracetamol or sodium salicylate given intragastrically 30 minutes before the administration of absolute ethanol or acidified aspirin dose-dependently reduced the formation of mucosal lesions. The generation of gastric mucosal prostaglandin-like activity increased with ethanol and was completely suppressed by acidified aspirin. Paracetamol or sodium salicylate given alone increased the generation of mucosal prostaglandin-like material. Indomethacin, the prostaglandin synthesis inhibitor, suppressed this effect and inhibited the protective influence of paracetamol or sodium salicylate on the production of gastric lesions.