RT Journal Article SR Electronic T1 Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 536 OP 540 DO 10.1136/gut.23.6.536 VO 23 IS 6 A1 Konturek, S J A1 Brzozowski, T A1 Piastucki, I A1 Radecki, T YR 1982 UL http://gut.bmj.com/content/23/6/536.abstract AB Paracetamol or sodium salicylate given intragastrically 30 minutes before the administration of absolute ethanol or acidified aspirin dose-dependently reduced the formation of mucosal lesions. The generation of gastric mucosal prostaglandin-like activity increased with ethanol and was completely suppressed by acidified aspirin. Paracetamol or sodium salicylate given alone increased the generation of mucosal prostaglandin-like material. Indomethacin, the prostaglandin synthesis inhibitor, suppressed this effect and inhibited the protective influence of paracetamol or sodium salicylate on the production of gastric lesions.