RT Journal Article
SR Electronic
T1 Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 545
OP 551
DO 10.1136/gut.23.6.545
VO 23
IS 6
A1 A G Morgan
A1 W A McAdam
A1 C Pacsoo
A1 A Darnborough
YR 1982
UL http://gut.bmj.com/content/23/6/545.abstract
AB One hundred patients with benign gastric ulceration were treated in a single-blind, endoscopically controlled trial to assess the relative efficacy of cimetidine (1 g daily) and Caved-S (six tablets daily). Ulcer healing was assessed after six weeks' treatment, and, if incomplete, after a further six weeks. There was no significant difference between the two drug regimens (approximately 63% at six weeks and 91% at 12 weeks). If an ulcer remains unhealed after 10 weeks' treatment the patient should undergo surgery. There was no difference in the relief of day pain between the two drug regimens but cimetidine was more effective over the first two weeks of treatment relieving night pain, than was Caved-S (p less than 0 . 02). After ulcer healing, drug dosage was reduced (cimetidine to 400 mg at night and Caved-S to two tablets twice daily). So far, 56 patients, 28 in each group, have completed the first year's maintenance treatment, and there have been four ulcer recurrences in each group (14%).