RT Journal Article
SR Electronic
T1 Inhibition of leucocyte motility and prevention of immune-complex experimental colitis by hydroxychloroquine.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 181
OP 187
DO 10.1136/gut.23.3.181
VO 23
IS 3
A1 J M Rhodes
A1 J E McLaughlin
A1 D J Brown
A1 L A Nuttall
A1 D P Jewell
YR 1982
UL http://gut.bmj.com/content/23/3/181.abstract
AB The inhibitory effects of hydroxychloroquine on leucocyte motility have been compared with those of prednisolone. It has been shown to have similar potency to prednisolone as an inhibitor of human neutrophil and monocyte motility. Hydroxychloroquine has then been compared with placebo in the prevention of an immune-complex experimental colitis in rabbits. Rectal biopsies were taken from rabbits 24 hours after initiation of colitis, coded, and graded histologically. The summated gradings for acute inflammation and goblet cell depletion had worsened more in the control rabbits (mean grade +6.7) than in the treated rabbits (mean grade +1.8) P less than 0.05. There was no difference in the mononuclear cell infiltrate between the two groups. Hydroxychloroquine, which is a potent inhibitor of leucocyte motility, effectively prevents the acute inflammatory infiltrate in this experimental colitis model and therefore merits trial in human ulcerative colitis.