RT Journal Article
SR Electronic
T1 Liver membrane antibodies in alcoholic liver disease: 1. prevalence and immunoglobulin class.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 221
OP 225
DO 10.1136/gut.23.3.221
VO 23
IS 3
A1 A D Burt
A1 R S Anthony
A1 W S Hislop
A1 I A Bouchier
A1 R N MacSween
YR 1982
UL http://gut.bmj.com/content/23/3/221.abstract
AB Using an indirect immunofluorescence technique liver membrane antibodies of IgG and IgA class have been demonstrated in a statistically significant proportion of sera from patients with alcoholic hepatitis and alcoholic cirrhosis. IgG and IgA class antibodies were found respectively in 23 and 25% of 48 patients with alcoholic hepatitis, in 27 and 33% of 84 with active cirrhosis, and 67 and 58% of 12 with inactive cirrhosis. These results provide evidence of a humoral immune response in alcoholic liver disease which is directed against, as yet undefined, liver-cell membrane antigens.