RT Journal Article SR Electronic T1 Inhibition of leucocyte motility by drugs used in ulcerative colitis. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 642 OP 647 DO 10.1136/gut.22.8.642 VO 22 IS 8 A1 J M Rhodes A1 T C Bartholomew A1 D P Jewell YR 1981 UL http://gut.bmj.com/content/22/8/642.abstract AB The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of leucocyte motility. Sulphapyridine and indomethacin are non-inhibitory. Inhibition of leucocyte motility may explain why sulphasalazine and 5 amino-salicylic acid are effective in ulcerative colitis while sulphapyridine is not. The lack of effect of indomethacin suggests that this action of sulphasalazine does not involve inhibition of prostaglandin synthesis.