PT  - JOURNAL ARTICLE
AU  - G Crama-Bohbouth
AU  - F T Bosman
AU  - B J Vermeer
AU  - A M van der Wal
AU  - I Biemond
AU  - I T Weterman
AU  - A S Peńa
TI  - Immunohistological findings in lip biopsy specimens from patients with Crohn's disease and healthy subjects.
AID  - 10.1136/gut.24.3.202
DP  - 1983 Mar 01
TA  - Gut
PG  - 202--205
VI  - 24
IP  - 3
4099  - http://gut.bmj.com/content/24/3/202.short
4100  - http://gut.bmj.com/content/24/3/202.full
SO  - Gut1983 Mar 01; 24
AB  - Biopsies of apparently normal buccal mucosa were taken from 14 patients with Crohn's disease and 13 healthy controls who were matched for dental status. Most patients had an increased number of lymphocytes around vessels in the subepithelial tissue and two showed fibrosis with moderate atrophy of minor glands. Plasma cells which contained immunoglobulin, predominantly IgA, were only found around minor salivary glands in both patients and controls. Quantitative studies showed a significant increase in the number of cells containing IgA in patients compared with controls. No correlation was found between immunoglobulin pattern and disease activity, age, sex, or duration of Crohn's disease. A significant correlation was found between the activity of the disease, as defined by the Crohn's Disease Activity Index, and the number of plasma cells containing IgM.