RT Journal Article
SR Electronic
T1 Immunohistological findings in lip biopsy specimens from patients with Crohn's disease and healthy subjects.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 202
OP 205
DO 10.1136/gut.24.3.202
VO 24
IS 3
A1 G Crama-Bohbouth
A1 F T Bosman
A1 B J Vermeer
A1 A M van der Wal
A1 I Biemond
A1 I T Weterman
A1 A S Peńa
YR 1983
UL http://gut.bmj.com/content/24/3/202.abstract
AB Biopsies of apparently normal buccal mucosa were taken from 14 patients with Crohn's disease and 13 healthy controls who were matched for dental status. Most patients had an increased number of lymphocytes around vessels in the subepithelial tissue and two showed fibrosis with moderate atrophy of minor glands. Plasma cells which contained immunoglobulin, predominantly IgA, were only found around minor salivary glands in both patients and controls. Quantitative studies showed a significant increase in the number of cells containing IgA in patients compared with controls. No correlation was found between immunoglobulin pattern and disease activity, age, sex, or duration of Crohn's disease. A significant correlation was found between the activity of the disease, as defined by the Crohn's Disease Activity Index, and the number of plasma cells containing IgM.