TY - JOUR T1 - Effect of gluten-free diet on splenic hypofunction of adult coeliac disease. JF - Gut JO - Gut SP - 228 LP - 230 DO - 10.1136/gut.24.3.228 VL - 24 IS - 3 AU - G R Corazza AU - M Frisoni AU - D Vaira AU - G Gasbarrini Y1 - 1983/03/01 UR - http://gut.bmj.com/content/24/3/228.abstract N2 - Splenic function has been serially measured by counting pitted red cells in 15 coeliac patients, before and during a gluten-free diet. The basal percentage values of pitted cells decreased significantly during treatment but no correlation was observed between the duration of the gluten-free diet and the percentage of recovery of splenic function over basal values. Out of six coeliacs with pitted cell values consistent with splenic hypofunction, three showed a total recovery after gluten withdrawal. Our data suggest that, contrary to recent reports, hyposplenism in adult coeliac disease is improved by a gluten-free diet, and that environmental factors may be important in determining and maintaining this complication. ER -