PT  - JOURNAL ARTICLE
AU  - C A Hughes
AU  - I C Talbot
AU  - D A Ducker
AU  - M J Harran
TI  - Total parenteral nutrition in infancy: effect on the liver and suggested pathogenesis
AID  - 10.1136/gut.24.3.241
DP  - 1983 Mar 01
TA  - Gut
PG  - 241--248
VI  - 24
IP  - 3
4099  - http://gut.bmj.com/content/24/3/241.short
4100  - http://gut.bmj.com/content/24/3/241.full
SO  - Gut1983 Mar 01; 24
AB  - Biochemical, histological, and electron-microscopic investigation of seven preterm infants who became jaundiced after prolonged total parenteral nutrition showed conjugated hyperbilirubinaemia apparently due to cholestasis without significant primary liver cell injury. In the absence of evidence indicating a direct toxic effect on the liver of this form of nutrition the necropsy findings in one child and analogy with the effects of total parenteral nutrition in animals suggest that the cholestasis is the result of suppression of trophic and/or secretion-stimulating hormone(s) normally produced by the gut, due to absent enteral nutrition. Biochemical and electron-microscopic findings suggest that liver cell damage occurs after resumption of enteral nutrition.