RT Journal Article
SR Electronic
T1 In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 378
OP 383
DO 10.1136/gut.26.4.378
VO 26
IS 4
A1 S H Saverymuttu
A1 A M Peters
A1 J P Lavender
A1 V S Chadwick
A1 H J Hodgson
YR 1985
UL http://gut.bmj.com/content/26/4/378.abstract
AB It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new approach which utilises dynamic gamma camera imaging after injection of 111In labelled autologous granulocytes. In 20 of 22 studies there was rapid migration to diseased bowel, compatible with no migration delay. Only two patients showed delays in migration of 12 and 15 minutes respectively, but neither had any clinical characteristics to distinguish them from the other 20 patients. This study shows that the majority of patients with Crohn's disease in relapse have rapid granulocyte migration to diseased bowel and provides evidence against a significant migration defect in this condition.