PT - JOURNAL ARTICLE AU - Savage, A P AU - Gornacz, G E AU - Adrian, T E AU - Ghatei, M A AU - Goodlad, R A AU - Wright, N A AU - Bloom, S R TI - Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response? AID - 10.1136/gut.26.12.1353 DP - 1985 Dec 01 TA - Gut PG - 1353--1358 VI - 26 IP - 12 4099 - http://gut.bmj.com/content/26/12/1353.short 4100 - http://gut.bmj.com/content/26/12/1353.full SO - Gut1985 Dec 01; 26 AB - The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.