PT  - JOURNAL ARTICLE
AU  - A P Savage
AU  - G E Gornacz
AU  - T E Adrian
AU  - M A Ghatei
AU  - R A Goodlad
AU  - N A Wright
AU  - S R Bloom
TI  - Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?
AID  - 10.1136/gut.26.12.1353
DP  - 1985 Dec 01
TA  - Gut
PG  - 1353--1358
VI  - 26
IP  - 12
4099  - http://gut.bmj.com/content/26/12/1353.short
4100  - http://gut.bmj.com/content/26/12/1353.full
SO  - Gut1985 Dec 01; 26
AB  - The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.