TY - JOUR T1 - Pentagastrin induced motility pattern in the human upper gastrointestinal tract is reversed by proglumide. JF - Gut JO - Gut SP - 953 LP - 956 DO - 10.1136/gut.25.9.953 VL - 25 IS - 9 AU - J F Erckenbrecht AU - J Caspari AU - M Wienbeck Y1 - 1984/09/01 UR - http://gut.bmj.com/content/25/9/953.abstract N2 - The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes after starting a pentagastrin infusion (0.15 micrograms/kg/h) either placebo or proglumide was infused intravenously. Pentagastrin converted the normal interdigestive motility to irregular motor activity, while proglumide restored the periodic fasted pattern. We conclude that gastrin is a likely candidate involved in the conversion of the fasted to the fed motility pattern in the human upper gut. ER -