RT Journal Article
SR Electronic
T1 Cronkhite Canada syndrome: a new hypothesis.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 531
OP 536
DO 10.1136/gut.26.5.531
VO 26
IS 5
A1 K Freeman
A1 P P Anthony
A1 D S Miller
A1 A P Warin
YR 1985
UL http://gut.bmj.com/content/26/5/531.abstract
AB The occurrence of Cronkhite Canada syndrome in a 78 year old man is described. The presence of total gastrointestinal mucosal atrophy with nail loss is reported for the first time. It is suggested that the polyps represent residues of aged cells with no absorptive function and that the condition results from the loss of normal proliferative stimuli or acquired resistance to them. The primary biochemical abnormality may be in the affected epithelia but the changes here could alternatively be secondary to failure of synthesis or release of growth factors.