PT - JOURNAL ARTICLE AU - E Bercoff AU - J Bernuau AU - C Degott AU - B Kalis AU - A Lemaire AU - H Tilly AU - B Rueff AU - J P Benhamou TI - Ketoconazole-induced fulminant hepatitis. AID - 10.1136/gut.26.6.636 DP - 1985 Jun 01 TA - Gut PG - 636--638 VI - 26 IP - 6 4099 - http://gut.bmj.com/content/26/6/636.short 4100 - http://gut.bmj.com/content/26/6/636.full SO - Gut1985 Jun 01; 26 AB - We report the cases of two adult patients in whom fulminant hepatitis developed after 17 and 103 days of ketoconazole administration. Histologic administration showed massive, predominantly centrilobular necrosis. Clinical manifestations of hypersensitivity and eosinophilia were absent in both patients, which suggests that ketoconazole hepatotoxicity is not mediated through an immunoallergic mechanism.