PT  - JOURNAL ARTICLE
AU  - T J Mitchell
AU  - J M Ketley
AU  - S C Haslam
AU  - J Stephen
AU  - D W Burdon
AU  - D C Candy
AU  - R Daniel
TI  - Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
AID  - 10.1136/gut.27.1.78
DP  - 1986 Jan 01
TA  - Gut
PG  - 78--85
VI  - 27
IP  - 1
4099  - http://gut.bmj.com/content/27/1/78.short
4100  - http://gut.bmj.com/content/27/1/78.full
SO  - Gut1986 Jan 01; 27
AB  - The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.