PT  - JOURNAL ARTICLE
AU  - P B Szecsi
AU  - H Halgreen
AU  - S S Poulsen
AU  - C K Axelsson
AU  - M Damkjaer-Nielsen
AU  - T Kjaer
AU  - B Foltmann
TI  - Demonstration of pepsinogen C in human pancreatic islets.
AID  - 10.1136/gut.28.10.1208
DP  - 1987 Oct 01
TA  - Gut
PG  - 1208--1214
VI  - 28
IP  - 10
4099  - http://gut.bmj.com/content/28/10/1208.short
4100  - http://gut.bmj.com/content/28/10/1208.full
SO  - Gut1987 Oct 01; 28
AB  - Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.