RT Journal Article
SR Electronic
T1 Effects of nifedipine on gastric acid secretion and gastrin release in man.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 455
OP 459
DO 10.1136/gut.28.4.455
VO 28
IS 4
A1 K E McColl
A1 N M Buchanan
A1 G Laferla
A1 J Hearns
A1 K Buchanan
A1 G P Crean
YR 1987
UL http://gut.bmj.com/content/28/4/455.abstract
AB As calcium is important in the regulation of gastric acid secretion and gastrin release, we have examined the effect of the calcium antagonist nifedipine on these processes in man. Nifedipine 30 mg orally inhibited basal acid output by 37% (p less than 0.025) and that stimulated by low infusion rates of pentagastrin--that is, 0.031 and 0.062 microgram/kg/h by 44% (p = 0.05) and 39% (p less than 0.02) respectively. On increasing the pentagastrin infusion rate the inhibition was surmounted suggesting it was competitive in type. Nifedipine did not affect basal or Oxo meal stimulated gastrin concentrations in normal volunteers nor did it affect resting serum gastrin or calcium stimulated increase in gastrin in a single patient with Zollinger-Ellison syndrome. These findings are consistent with the transmembrane flux of calcium ions being involved in basal and pentagastrin stimulated acid secretion in man.