RT Journal Article
SR Electronic
T1 Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1267
OP 1274
DO 10.1136/gut.28.10.1267
VO 28
IS 10
A1 M E Baca
A1 A M Mowat
A1 S MacKenzie
A1 D M Parrott
YR 1987
UL http://gut.bmj.com/content/28/10/1267.abstract
AB In this study we have investigated whether addition of bone marrow accessory cells or concurrent administration of recombinant IL-2 would allow intraepithelial lymphocytes (IEL) to induce a systemic, lethal GvHR in irradiated hosts. In addition we have studied the ability of IEL to migrate into lymphoid tissues after intravenous injection and compared this with their locomotor capacity in vitro.