RT Journal Article SR Electronic T1 Salicylate induced exacerbation of ulcerative colitis. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 613 OP 615 DO 10.1136/gut.28.5.613 VO 28 IS 5 A1 Chakraborty, T K A1 Bhatia, D A1 Heading, R C A1 Ford, M J YR 1987 UL http://gut.bmj.com/content/28/5/613.abstract AB The oral administration of mesalazine (5-aminosalicylic acid) resulted in the exacerbation of ulcerative colitis in two patients intolerant to sulphasalazine whose colitis had previously been quiescent. Although sulphasalazine intolerance is usually attributable to the sulphapyridine moiety, the possibility of salicylate sensitivity should be considered in colitic patients who fail to respond appropriately to sulphasalazine or who experience abdominal pain or diarrhoea while taking the drug.