RT Journal Article
SR Electronic
T1 Effects of fasting and refeeding on somatostatin concentration and binding to cytosol from rabbit gastric mucosa.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 642
OP 646
DO 10.1136/gut.29.5.642
VO 29
IS 5
A1 B Roca
A1 R Fernandez-Valencia
A1 E Arilla
YR 1988
UL http://gut.bmj.com/content/29/5/642.abstract
AB Somatostatin like immunoreactivity and the density of somatostatin binding sites were measured in stomach (fundus and antrum) from either fed, 12 to 96 hours fasted, or 96 hours fasted plus 48 hours refed rabbits. The somatostatin concentration increased in fundic and antral mucosa after 24 h and reached its highest value after 96 h of fasting. The number of specific somatostatin binding sites with high and low affinity decreased with the duration of fasting. Refeeding of fasted animals resulted in a normalisation to control values of gastric mucosal somatostatin and somatostatin binding.