RT Journal Article
SR Electronic
T1 Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 675
OP 681
DO 10.1136/gut.29.5.675
VO 29
IS 5
A1 J P Galmiche
A1 G Brandstätter
A1 M Evreux
A1 E Hentschel
A1 E Kerstan
A1 P Kratochvil
A1 W Reichel
A1 K Schütze
A1 J C Soule
A1 J Vitaux
YR 1988
UL http://gut.bmj.com/content/29/5/675.abstract
AB Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis.