TY - JOUR T1 - Somatostatin inhibits the effect of secretin on bile flow and on hepatic bilirubin transport in the rat. JF - Gut JO - Gut SP - 1266 LP - 1269 DO - 10.1136/gut.30.9.1266 VL - 30 IS - 9 AU - G L Ricci AU - J Fevery Y1 - 1989/09/01 UR - http://gut.bmj.com/content/30/9/1266.abstract N2 - Increasing amounts of porcine secretion (0.05 to 2.00 clinical units/h/100 g body wt) given to rats during a continuous infusion of bilirubin, increased bile flow and the apparent maximal biliary excretion of bilirubin ('Tm'). This increment was caused by an enhanced biliary output of bilirubin monoconjugates. The effect was dose dependent but maximal at a secretin infusion of 0.80 CU. Somatostatin 0.2 and 0.8 microgram/h/100 g body wt caused a dose related inhibition of the hepatic effects of secretin both on bile flow and on biliary output of bilirubin conjugates. As secretin elicits the release of somatostatin, a feed-back system could be envisaged whereby the somatostatin released stops the effects of secretin. ER -