RT Journal Article
SR Electronic
T1 Ulcerative colitis: one disease or two? (Quantitative histological differences between distal and extensive disease).
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 426
OP 430
DO 10.1136/gut.31.4.426
VO 31
IS 4
A1 D Jenkins
A1 A Goodall
A1 B B Scott
YR 1990
UL http://gut.bmj.com/content/31/4/426.abstract
AB Cell counts and measurements of mucosal architecture were made on rectal biopsies from nine patients with total colitis, eight with left sided colitis, 15 with distal colitis, and 11 with proctitis. The mean total lamina propria cell count in proctitis and distal colitis approached twice that of extensive left sided and total colitis (p less than 0.001) and in distal proctocolitis the cell numbers are further increased in the chronic over the acute phase. This difference was not explained by age, duration, activity, or treatment. The predominantly increased lymphoid and mononuclear cell infiltrate in distal proctocolitis indicates a different pattern of immune response, suggesting a separate process from extensive colitis or a more intense reaction resulting in localisation of disease.