PT  - JOURNAL ARTICLE
AU  - Srivastava, E D
AU  - Russell, M A
AU  - Feyerabend, C
AU  - Rhodes, J
TI  - Effect of ulcerative colitis and smoking on rectal blood flow.
AID  - 10.1136/gut.31.9.1021
DP  - 1990 Sep 01
TA  - Gut
PG  - 1021--1024
VI  - 31
IP  - 9
4099  - http://gut.bmj.com/content/31/9/1021.short
4100  - http://gut.bmj.com/content/31/9/1021.full
SO  - Gut1990 Sep 01; 31
AB  - Rectal blood flow was measured by laser doppler flowmetry over 60 minutes in eight patients with colitis in remission and eight healthy male non-smokers. Ten smokers were also examined on two occasions, one of which included smoking a cigarette. Plasma nicotine concentrations were measured in smokers. All subjects showed a pronounced fall in rectal blood flow in the first 30 minutes and patients with colitis had significantly higher values compared with smokers (p less than 0.002; p less than 0.04) and non-smokers (p less than 0.007; p less than 0.002) during the first and second 30 minutes respectively. Values in smokers and non-smokers were similar, but smoking a cigarette was associated with a significant fall in blood flow (p less than 0.04) and this change was inversely related to the rise in plasma nicotine concentration (r = -0.63; p less than 0.05). The findings may be relevant to the association between colitis and the smoking history.