RT Journal Article SR Electronic T1 Histamine concentration of gastric mucosa in Helicobacter pylori positive and negative children. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 464 OP 466 DO 10.1136/gut.32.5.464 VO 32 IS 5 A1 D M Queiroz A1 E N Mendes A1 G A Rocha A1 A J Barbosa A1 A S Carvalho A1 J R Cunha-Melo YR 1991 UL http://gut.bmj.com/content/32/5/464.abstract AB The histamine concentration was determined by enzymatic isotopic method in biopsy specimens of oxyntic mucosa from 37 children. Nineteen of the 37 had Helicobacter pylori associated gastritis (9 with duodenal ulcer). The histamine concentration in the H pylori negative group was mean (SD) 54.1 (23.1) micrograms/g fresh weight, and that in the H pylori positive group was 26.3 (14.2) micrograms/g (p less than 0.01). There was also a significant difference between H pylori positive patients with duodenal ulcer (19.8 (6.3) micrograms/g) and those without ulcer (31.4 (17.9) micrograms/g) (p less than 0.05). These results suggest that H pylori positive patients, especially those with duodenal ulcer, have reduced 'stored' histamine, perhaps because of increased histamine liberation.