TY - JOUR T1 - Inhibition of red cell membrane lipid peroxidation by sulphasalazine and 5-aminosalicylic acid. JF - Gut JO - Gut SP - 1156 LP - 1159 DO - 10.1136/gut.32.10.1156 VL - 32 IS - 10 AU - S M Greenfield AU - N A Punchard AU - R P Thompson Y1 - 1991/10/01 UR - http://gut.bmj.com/content/32/10/1156.abstract N2 - The effects of sulphasalazine, 5-aminosalicylic acid (5-ASA), and sulphapyridine on peroxidation of red cell membrane lipids, measured as malondialdehyde production, were assessed. Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action that may explain the efficacy of these drugs in treating inflammatory bowel disease. Sulphapyridine, which is not effective in inflammatory bowel disease inhibited malondialdehyde production at a concentration of 10(-3) M only. ER -