PT  - JOURNAL ARTICLE
AU  - Challacombe, D N
AU  - Wheeler, E E
TI  - Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro.
AID  - 10.1136/gut.32.9.991
DP  - 1991 Sep 01
TA  - Gut
PG  - 991--993
VI  - 32
IP  - 9
4099  - http://gut.bmj.com/content/32/9/991.short
4100  - http://gut.bmj.com/content/32/9/991.full
SO  - Gut1991 Sep 01; 32
AB  - The action of epidermal growth factor on the human duodenal mucosa has been studied by estimating the crypt cell production rate in cultured explants, using a stathmokinetic technique with crypt microdissection. The addition of epidermal growth factor (400 ng/ml) to paired explants from five patients caused an almost fivefold increase in the crypt cell production rate, showing that epidermal growth factor has a trophic action on the human duodenal mucosa in vitro.