TY - JOUR T1 - Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine. JF - Gut JO - Gut SP - S106 LP - S106 DO - 10.1136/gut.34.2_Suppl.S106 VL - 34 IS - 2 Suppl AU - P Marcellin AU - N Boyer AU - J F Colin AU - M Martinot-Peignoux AU - V Lefort AU - S Matheron AU - S Erlinger AU - J P Benhamou Y1 - 1993/01/01 UR - http://gut.bmj.com/content/34/2_Suppl/S106.abstract N2 - In this pilot study of the effects of interferon alfa in 10 anti-HIV positive, chronic hepatitis B patients treated with zidovudine (AZT), tolerance to interferon was good and similar to that in anti-HIV negative patients. After treatment, the HIV stage and CD4 lymphocyte count were unchanged. In two patients hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg) disappeared and the serum alanine aminotransferase (ALT) returned to normal; loss of hepatitis B surface antigen (HBsAg) with absence of histopathological activity was observed after treatment in one of these patients. These preliminary results need to be confirmed by a larger study. ER -